Oxidative Cellular Damage and the Reduction of APE/Ref-1 Expression after Experimental Traumatic Brain Injury
The Janitorial DNA repair enzyme, apurinic/apyrimidinic endonuclease (or redox effector factor-1, APE/Ref-1), is involved in base excision repair of apurinic/apyrimidinic sites after oxidative DNA damage.We investigated the expression of APE/Ref-1 and its relationship to oxidative stress after severe traumatic brain injury produced by controlled co